Find articles by Cristoforo Pomara Giorgio I. Associated Data All data generated or analyzed during this study are included in this published article. Abstract The current challenge worldwide is the administration of the severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 vaccine. Moreover, this review aims to provide key recommendations to improve awareness of vaccine safety. We included 17 papers published with fatal cases with post-mortem investigations. Based on these data, autopsy is very useful to define the main characteristics of the so-called vaccine-induced immune thrombotic thrombocytopenia VITT after ChAdOx1 nCoV vaccination: recurrent findings were intracranial hemorrhage and diffused microthrombi located in multiple areas. Finally, based on the discussed data, we suggest several key recommendations to improve awareness of vaccine safety. The virus rapidly spread around the world, leading to one of the most severe pandemics in human history: on 2 Decemberthere were , cases worldwide, with more than 5, confirmed deaths, affecting countries [ 2 ].
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